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The Graham Lab - Wellcome Project Group

The project aims to investigate the role of the iCCR cluster (CCR1, CCR2, CCR3 and CCR5) in health and disease using novel  mouse models targeting this cluster. These include a multi-receptor knock-out (KO), a multi-receptor reporter and a conditional KO strain. 

Postdocs

Dr. Catherine Hughes

About Catherine

Catherine is Laboratory Manager for the whole CRG as well as a postdoctoral researcher within the Wellcome group.

"My research focuses on the role of “inflammatory” CC chemokine receptors in cell migration. Using the novel multi-receptor knock-out and reporter mice generated by our group, I aim to understand the subtle specificities contained within these often overlapping and complex receptor-ligand families, both at rest but particularly in disease.

Outside the lab I "enjoy" attempting various fitness challenges, like fun runs and triathlons, with varying degrees of success (and pretty much one speed - slow!)."

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Dr. Laura Medina Ruiz

About Laura

Laura Medina is a postdoctoral Research Associate for Professor Gerry Graham, currently funded by Wellcome. Her work is aimed at identifying the role of the inflammatory CC chemokine receptors (iCCRs) 1, 2, 3 and 5 in the orchestration of the inflammatory response.

Due to their overlapping expression patterns and their apparent functional redundancy, attempts to define a role for each of the iCCRs have been difficult. For this reason, Laura’s work is focused on the generation of iCCR-reporter mice to define the temporal and cell-specific dynamics of expression of these chemokine receptors during inflammation.

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Dr. Fabian Schuette

About Fabian

Fabian is a postdoctoral Research Associate in the Graham Lab, currently funded by Wellcome.

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Ph.D. Students

Robin Bartolini

About Robin

"I am Robin Bartolini, a graduate from University of Glasgow in Immunology. Here at Glasgow, I am currently interested in the development of the chemokine driven inflammatory response. During my PhD project, I will be trying to assess the importance of chemokine receptors in the immune response by using two novel mouse models: 

an inflammatory chemokine receptor KO strain lacking chemokine receptors CCR1, CCR2, CCR3 and CCR5 and an inflammatory chemokine fluorescent reporter strain". 

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